The Thyroid - Serotonin Connection

Serotonin is intimately bound with thyroid hormone. Healthy thyroid function plays an important role in supporting healthy serotonin production and concentration, as well as preventing serotonin reuptake. As a result, strong, healthy thyroid levels result in an increased level of serotonin in the brain. 

If you exhibit symptoms of low thyroid, you can work to increase your serotonin levels in conjunction with increasing thyroid hormones.

To maintain proper serotonin levels, aim for 50–100 mg of 5-HTP once or twice a day, with one of the dosages taken at bedtime. If needed during the day, use carefully, as too much 5-HTP can interfere with your ability to drive or concentrate.

Be sure to start at 50 mg. Stay on this dosage for two weeks. If you don’t notice a reduction in your symptoms, gradually increase the dosage by 50 mg every two weeks until you have either noticed a reduction in your symptoms or have reached the maximum dosage. 

Finally, you can also try L-tyrosine, an amino acid produced in the body from phenylalanine (another amino acid), plays a crucial role in supporting the thyroid gland. It works to produce thyroid hormone and keep thyroid production balanced. 

Tyrosine also revs up metabolism and boosts stamina. It is the precursor for the thyroid hormone that drives metabolism, as well as the precursor for dopamine, norepinephrine, and epinephrine (nervous-system chemicals that affect metabolism, mental alertness, and energy levels). 

Tyrosine is abundant in fish, soybeans, poultry, meat, almonds, seeds, and peas. If you prefer to take a supplement, aim for 500– 2,000 mg of tyrosine per day with a protein meal. Those with high blood pressure should begin with the lower dosage, and monitor blood pressure levels regularly. Note: Tyrosine is an ideal complement to thyroid medication, not a substitute for it. 


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